Application of Escherichia coli-Derived Recombinant Human Bone Morphogenic Protein-2 to Unstable Spinal Fractures

Acute Intravenous Injection Toxicity Study of Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 in Rat

STUDY DESIGN Prospective in vivo toxicity study. PURPOSE To evaluate the conducted acute toxicity study of Escherichia coli (E. coli)-derived recombinant human bone morphogenetic protein-2 (rhBMP-2) with 6-weeks old Sprague-Dawley rats. OVERVIEW OF LITERATURE rhBMP-2 has well-known osteoinductivity and it is used as a bone graft substitute. E. coli-derived rhBMP-2 can be mass-produced with ...

RECOMBINANT HUMAN BONE MORPHOGENIC PROTEIN-2 (rhBMP-2) USE IN MAXILLOFACIAL SURGERY

Surgeons can now control osteogenesis through local application of BMP-2. BMP’s are osteoinductive proteins that are located in bone matrix and are responsible for embryonic skeletal formation and bone healing. Marshal Urist first coined the term “bone morphogenic protein” over 40 years ago. Recombinant human BMP-2 is an osteoinductive growth factor that has the potential to make autogenous bon...

Bone Morphogenic Protein Use in Spinal Surgery.

Bone morphogenic protein (BMP) provides excellent enhancement of fusion in many spinal surgeries. BMP should be a cautionary tale about the use of industry-sponsored research, perceived conflicts of interest, and holding the field of spinal surgery to the highest academic scrutiny and ethical standards. In the case of BMP, not having a transparent base of literature as it was approved led to de...

Advances and challenges in recombinant protein expression in Escherichia coli

Escherichia coli-derived recombinant human bone morphogenetic protein-2 combined with bone marrow-derived mesenchymal stromal cells improves bone regeneration in canine segmental ulnar defects

BACKGROUND Large bone defects in canines usually require assistance to achieve healing. Implantation of osteoinductive factors can promote bone healing, while transplantation of osteoprogenitor cells can enhance bone regeneration. We hypothesized that implantation of an osteoinductive factor, recombinant human bone morphogenetic protein-2 (rhBMP-2), combined with osteoprogenitor cells, bone mar...